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用于核酸输送的光触发纳米载体.

Baihao Huang1,2, Stefaan C De Smedt1, Winnok H De Vos2

  • 1Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.

Drug delivery
|May 14, 2025
PubMed
概括

光触发载体为基因治疗提供了一个有希望的,生物相容的替代方案. 这些先进的系统提高了将治疗性核酸 (NA) 输送到细胞中的效率,克服了潜在临床应用的关键生物障碍.

关键词:
基因治疗是一种基因疗法.细胞内屏障 细胞内屏障通过光触发的交付.核酸核酸是一种核酸.用于翻译的使用.

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...