在药物流产期间,德波梅德罗西孕酸对米费普里斯的作用的影响
Mitchell D Creinin1, Christy M Boraas2,3
1Department of Obstetrics and Gynecology, University of California, Davis, Sacramento, CA, USA.
概括
与米费普里斯一起使用德波-麦德洛西孕酸 (DMPA) 可能会增加药物流产中的持续怀孕风险,特别是在更晚的妊娠期间. 需要进一步的研究来澄清DMPA对米费普里斯有效性的影响.
科学领域:
- 生殖健康 生殖健康
- 药理学 药理学是指药理学的学科.
- 产科和妇科 产科和妇科
背景情况:
- 使用米费普里斯和米索普罗斯托尔进行药物流产是一种常见的程序.
- 德波-麦德洛西孕酸 (DMPA) 是一种孕激素避孕药,可能与米费普里斯相互作用.
- 了解同时使用的影响对于患者咨询和治疗方案至关重要.
研究的目的:
- 根据怀孕期的持续时间来评估药物流产的结果,在接受米费普里斯顿与或没有同时服用DMPA的患者中.
- 估计DMPA对米费普里斯在药物堕胎中的疗效的特定影响.
主要方法:
- 一个回顾性研究的二次分析.
- 治疗失败的评估,特别是正在进行的怀孕,按妊娠时间划分.
- 文献评估以估计mizoprostol的基线疗效和mifepristone和DMPA的添加作用.
主要成果:
- 在DMPA和非DMPA组中,持续怀孕率随着妊娠时间的增加而增加.
- 没有观察到在特定妊娠持续时间层内的群体之间的结果有统计学意义上的差异,这可能是由于样本大小小.
- 同时服用DMPA和米费普里斯,总体而言,持续怀孕的可能性增加了25.3%,对于怀孕时间≤49天的怀孕,增加了16.1%.
结论:
- 持续的怀孕作为药物流产失败的原因是更常见的随着妊娠的推进,无论使用DMPA.
- 根据妊娠时间,DMPA可能会对米费普里斯顿的疗效产生不同的影响.
- 需要进行更大规模的研究才能确定DMPA和米费普里斯在药物堕胎中的相互作用.
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