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低成本的机器人操纵活微组织,用于癌症药物测试

Ivan Stepanov^1,2, Noah R Gottshall¹, Alireza Ahmadianyazdi¹

¹Department of Bioengineering, University of Washington, Seattle, WA, USA.

Science advances

|May 14, 2025

概括

一个新的,负担得起的机器人平台使得微流体操纵活微组织从患者活检的药物测试. 这项技术使先进的药物评估可用于制药,临床和生物实验室.

科学领域:

生物技术是生物技术.
药物发现药物发现药物发现
微流体学微流体学

背景情况:

人体活检的稀缺性阻碍了药物开发和个性化医学.
目前用于组织操纵的微技术由于成本和复杂性,往往无法获得.
存在对微组织药物测试的可访问平台的需求.

研究的目的:

开发一种廉价且易于使用的机器人平台,用于对活微组织进行微流体操纵.
用患者瘤活检演示概念验证药物评估工作流程.
扩大微组织药物检测的可访问性.

主要方法:

用于微流体操纵的现成机器人的快速原型设计.
将复杂的功能集成到一个简单,经济高效,紧的机器人中.
癌症药物评估工作流程的演示,使用患者瘤活检在384个井板中.

主要成果:

成功开发了一个用户友好的,低成本的机器人平台用于微组织操纵.
通过患者瘤活检和多种药物展示了癌症药物评估工作流.
平台在组织培养罩内运行,用于无复杂附件的无菌工作流.

结论:

开发的平台显著提高了微组织药物测试的可访问性.
这种创新可以加速治疗开发,疾病建模和个性化治疗.
该技术对制药,临床和生物研究实验室具有前景.

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