国家依赖的关联性可塑性突出显示了功能特定的前运动-运动路径,这对于任意视觉运动映射至关重要
Sonia Turrini1, Francesca Fiori1,2, Giorgio Arcara3
1Centro studi e ricerche in Neuroscienze Cognitive, Dipartimento di Psicologia "Renzo Canestrari," Alma Mater Studiorum Università di Bologna Campus di Cesena, 47521 Cesena, Italy.
Science advances
|May 14, 2025
概括
这项研究揭示了大脑.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 认知科学 认知科学
背景情况:
- 任意视觉运动映射 (AVMM) 证明了大脑将感官刺激与运动行为联系在一起的能力.
- 假设腹前运动皮层 (PMv) 和主要运动皮层 (M1) 途径对于AVMM中的感觉运动转换至关重要.
- 对于PMv-M1通路在AVMM中的作用的直接证据是有限的.
研究的目的:
- 研究PMv-M1连接在任意视觉运动映射 (AVMM) 中的因果作用.
- 使用皮层-皮层配对关联刺激 (ccPAS) 探索PMv-M1通路的可塑性.
- 确定依赖状态的ccPAS是否可以选择性调节参与AVMM的视觉运动神经元.
主要方法:
- 四个实验使用皮层-皮层配对关联刺激 (ccPAS) 来调节PMv-to-M1连接.
- 使用依赖于状态的横磁刺激 (TMS) 来针对特定功能的神经群体.
- ccPASPMv-M1旨在增强连接性,而ccPASM1-PMv则旨在在视觉运动任务中抑制它.
主要成果:
- 国家依赖的ccPASPMv-M1增强了AVMM的神经生理和行为指标.
- 相反,ccPASM1-PMv表明对AVMM的性能有抑制作用.
- 与对照线索相比,当响应目标视觉线索时,这些调制效应更为显著.
结论:
- PMv-M1通路表现出可塑性,并在任意视觉运动映射 (AVMM) 中起因作用.
- 在PMv-M1通路内的空间重叠但功能上不同的神经群体参与了AVMM.
- 国家依赖的ccPAS是针对特定视觉运动通路的有针对性的调制的可行工具.
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