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目前和未来的早期胰腺癌全球负担:基于人口的研究
Lucas Diniz da Conceição1, Luís Felipe Leite da Silva1, Mariana Macambira Noronha2
1Department of Medical Sciences, Universidade Federal Fluminense, Rio de Janeiro, Brazil.
JCO global oncology
|May 14, 2025
概括
早期发生的胰腺癌 (EOPC) 在全球范围内正在增加,病例和死亡人数在上升,特别是在中低中等收入地区. 解决吸烟等危险因素对于未来的预防至关重要.
科学领域:
- 流行病学 流行病学
- 全球健康 全球健康
- 在瘤学瘤学.
背景情况:
- 早期发生的胰腺癌 (EOPC),在50岁之前被诊断出来,代表着日益增长的全球健康挑战.
- 了解EOPC趋势对于公共卫生战略至关重要.
研究的目的:
- 评估EOPC发病率和死亡率的全球趋势.
- 确定相关的风险因素,并预测到2040年EOPC的未来负担.
主要方法:
- 使用2021年全球疾病,伤害和风险因素负担研究的基于人口的分析.
- 包括来自204个国家和地区的数据,将EOPC定义为15-49岁的胰腺癌.
- 使用R和Python进行的统计分析.
主要成果:
- 从1990年到2021年,全球EOPC病例增加了1.63倍,死亡率增加了57%.
- 中等社会人口统计指数 (SDI) 地区的增长最快.
- 吸烟,高禁食血葡萄糖和高BMI是导致EOPC死亡的重要因素.
结论:
- 全球EOPC发病率和死亡率正在上升,中低中SDI地区的不成比例上升.
- 迫切需要进行初级预防,改善诊断和公平的医疗保健系统.
- 针对可修改的风险因素,如吸烟和代谢综合征,对于减轻EOPC的影响至关重要.
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