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在卵巢卵泡中的体外胃素释放反应

Chunheng Mo¹, Can Lv², Guoqiang Zhu²

¹Key laboratory of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, PR China; Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan University, Chengdu 610065, PR China; Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, Chengdu 610041, PR China.

Poultry science

|May 14, 2025

概括

胃蛋白释放 (GRP) 和它的受体 (GRPR) 通过刺激粒状细胞的增殖,促进卵巢卵泡的生长. 这条涉及MAPK/ERK和HB-EGF的途径补充了毛囊发育中的淋巴激素作用.

科学领域:

生殖生物学生殖生物学
内分泌学在内分泌学.
细胞信号传递细胞信号传递

背景情况:

胃素释放 (GRP) 主要由的垂体产生.
它的受体 (GRPR) 在卵巢中高度表达,这表明它在卵巢功能中的作用.

研究的目的:

在实验室中研究GRP和GRPR在调节卵巢卵泡生长中的作用.
阐明参与GRP介导的毛囊发育的细胞机制.

主要方法:

在实验室培养早期卵巢毛囊 (1-6毫米) 的颗粒细胞.
在粒粉和甲基细胞中对GRPR表达的分析.
评估GRP对MAPK/ERK信号通路激活和粒粉细胞增殖的影响.
测量肝素结合性EGF类似生长因子 (HB-EGF) 的表达.

主要成果:

在早期毛囊 (1-6毫米) 的粒状细胞中,GRPR的表达很高,但在theca细胞中没有.
在培养的粒状细胞中,GRP激活了细胞内MAPK/ERK信号通路.
GRP促进了颗粒细胞的增殖,并增强了HB-EGF的表达.
早期毛囊中的GRPR表达与晚期毛囊中的FSHR和LHR表达形成鲜明对比.

结论:

在卵巢卵泡发育的早期阶段,GRP和GRPR起着重要的作用.
GRP通过MAPK/ERK通路和HB-EGF促进颗粒状细胞的增殖.
GRP信号与淋巴激素 (LH和FSH) 协调,以支持的卵泡生长.

关键词:

肉肉肉肉在GRP中,GRP是GRP.这就是为什么GRPR是GRPR.细胞质的花素.卵巢的卵泡是卵巢的卵泡.

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