双相情感障碍的纵向功能连接性研究:从默认模式网络及其与基因表达相关性的角度来看
Xuhan Cui1, Yiding Han1, Haohao Yan1
1Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China.
Journal of psychiatric research
|May 14, 2025
概括
这项纵向研究揭示了治疗后双相情感障碍 (BD) 患者的默认模式网络 (DMN) 功能连接 (FC) 的变化. 图像转录组学为BD提供了对BD的新见解.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 遗传学 是一个
背景情况:
- 默认模式网络 (DMN) 中的异常大脑活动与双相情感障碍 (BD) 有关.
- 之前对BD中DMN的研究主要是横截面的,限制了对其动态变化的理解.
研究的目的:
- 纵向研究DMN功能连接 (FC) 的演变模式及其与接受治疗的BD患者症状变化的关系.
- 探索成像转录学在识别与观察到的BD.中的FC变化相关的遗传因素的潜力.
主要方法:
- 一项纵向研究涉及82名BD患者和88名健康对照,其中43名BD患者完成了为期3个月的药物治疗随访.
- 进行了基于种子的功能连接 (FC) 分析,使用多重回归方法将FC变化与临床症状相关联.
- 利用艾伦人类大脑图谱 (Allen Human Brain Atlas) 的成像转录学被用来找到FC变化和基因表达模式之间的空间相关性.
主要成果:
- 患有BD的患者最初在DMN和包括轨道前皮层 (OFC) 和小脑在内的区域之间增加了FC.
- 在治疗后,DMN-OFC连接倾向于正常化,同时观察到下侧回 (IPG) 内的FC下降.
- 左侧IPG的特定FC变化与Stroop色词测试的表现有显著的相关性,相关基因与核糖体功能,膜运输和酶活性有关.
结论:
- 在双相情感障碍中,DMN的功能连接似乎与症状波动和治疗反应有关.
- 图像转录组学为研究BD的遗传基础提供了一种新的方法.
- 该研究承认对样本大小和单一中心数据的局限性,建议谨慎对研究结果进行概括.
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