臭氧的声波透皮转移及其在氧-臭氧治疗中的使用. 小麦和小麦
Salvatore Chirumbolo1, Luigi Valdenassi2, Umberto Tirelli3
1Department of Engineering for Innovation Medicine, University of Verona, Verona, Italy.
与针头注射相比,声波透皮传递 (STDT) 在氧气臭氧治疗中效率低下. STDT显示,在脊椎间盘退行治疗中,臭氧输送和治疗结果显著降低.
科学领域:
- 生物医学工程 生物医学工程
- 医学物理 医学物理
- 再生医学是一种再生医学.
背景情况:
- 氧气臭氧治疗用于各种疾病,但注射可能会让人感到不舒服.
- 声波透皮传输 (STDT) 为气体输送提供了一个非侵入性的替代方案.
- 椎间盘退化 (IVDD) 是一种可能通过臭氧治疗治疗的疾病.
研究的目的:
- 为了比较STDT的效率与用于输送臭氧的注射针的效率.
- 分析IVDD治疗中的臭氧扩散,稳定性和治疗结果.
- 评估STDT在医疗臭氧管理中的实际可行性.
主要方法:
- 对臭氧转移效率的比较分析.
- 评估臭氧扩散机制和生物化学稳定性.
- 在IVDD中对治疗结果和治愈概率的计算建模.
- 在优化的STDT条件下进行评估 (3MPa,3MHz).
主要成果:
- 在10分钟的时间里,STDT仅实现了~28%的臭氧转移效率,而通过注射针即时输送的效率为~92%.
- 臭氧在生物组织中的不稳定性限制了它在STDT期间的治疗可用性.
- 计算模型预测STDT的治愈概率为~50%,IVDD注射针的治愈概率为~95%.
- 在STDT中,臭氧的透和保留在组织中显著降低.
结论:
- 与针头注射相比,STDT目前是治疗性臭氧输送的未经证实且效率较低的方法.
- 皮肤透性和臭氧不稳定性对STDT构成重大挑战.
- 注射针仍然是医疗治疗中精确和高效的臭氧管理的优越方法.
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