在资源有限的环境中,全基性输血对烧伤死亡率的影响
Melissa Issa-Boube1, Jotham Gondwe2, Jared Gallaher3
1Morehouse School of Medicine, Atlanta, Georgia.
概括
全基因输血增加了烧伤患者的死亡风险,特别是随着年龄的增加和输血单位的增加. 在资源有限的环境中,建议采用限制性输血策略.
科学领域:
- 医学研究 医学研究
- 创伤外科 手术 创伤外科
- 血液学 血液学 血液学
背景情况:
- 全球发生了数百万个新的烧伤病例,不成比例地影响了低收入和中等收入国家.
- 烧伤患者往往需要输血,但对资源有限的高贫血环境中输血效应的数据很少.
- 这项研究调查了全基性输血对烧伤患者死亡率的影响.
研究的目的:
- 为了确定异构输血对烧伤死亡率的影响.
- 为了确定烧伤患者死亡率的预测因素.
- 在资源有限的环境中为输血指南提供信息.
主要方法:
- 从卡穆祖中央医院烧伤登记处对2359名烧伤患者 (2011-2019) 的回顾性审查.
- 多变量后勤回归建模以确定死亡率预测因素.
- 对患者人口统计,烧伤严重程度 (%TBSA),损伤类型和输血状态的分析.
主要成果:
- 同源性输血的死亡风险是同源性输血的1.23倍 (p < 0.03).
- 随着患者的年龄和输血的血液单位数量增加,死亡风险增加.
- 输血显示了40%以下的TBSA死亡率增加,但40%以上的TBSA死亡率降低.
结论:
- 全基因输血与烧伤患者的死亡率增加有关.
- 年龄和输血单位是影响死亡风险的重要因素.
- 资源有限的环境可能会受益于对烧伤患者的更严格的输血协议.
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