小神经纤维损伤和心脏自主功能障碍在患有高甘油三血症的患者
Bilal Bashir1, Raabya Pasha2, Anoushka Kamath2
1Faculty of Biology, Medicine and Health, University of Manchester, United Kingdom; Department of Endocrinology, Diabetes & Metabolism, Manchester University NHS Foundation Trust, United Kingdom; NIHR/WELLCOME Trust Clinical Research Facility, Manchester, United Kingdom.
高水平的甘油三 (HTG) 与神经损伤和心脏功能问题有关,即使没有糖尿病. 这项研究发现小神经纤维损伤和心脏自主功能障碍在个人HTG.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 过高甘油三血症 (HTG) 是糖尿病和肥胖患者中小纤维神经病变的已知危险因素.
- 在非糖尿病患者中,HTG与神经病变之间的关联需要进一步研究.
研究的目的:
- 在没有糖尿病的HTG患者中评估小神经纤维损伤.
- 在没有糖尿病的HTG患者中评估心脏自主功能障碍.
主要方法:
- 60名HTG患者和31名对照患者的队列接受了脂质特征评估.
- 通过对焦显微镜评估神经病变症状,角膜神经结构和心脏自主功能.
- 角膜共聚焦显微镜 (CCM) 评估了角膜神经纤维密度,分支密度和长度.
主要成果:
- 与对照组相比,患有HTG的个体表现出明显更高的甘油三水平和更低的HDL-C.
- 超高压组显示神经病症得分和振动感知值增加.
- 在HTG组中观察到角膜神经结构减少和心脏自主功能测试受损 (DB-HRV,EI比率,Valsalva比率,30-15比率).
结论:
- 独立于糖尿病的高甘油三血症与神经病变症状和小神经纤维损伤有关.
- 高血压还与心脏自主功能障碍有关,这表明它对神经系统有更广泛的影响.
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