成人并发症评估27和查尔森并发症指数在头部和部瘤学中的比较
Sierat Ahmad Khan1, Diako Berzenji1, Atilla Gül2
1Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer Institute, Erasmus University Medical Center, Doctor Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.
Oral oncology
|May 14, 2025
概括
成人并发症评估-27 (ACE-27) 和查尔森并发症指数 (CCI) 同样预测了头部和部状细胞癌 (HNSCC) 患者的生存率. 这些并发症指标在HNSCC的临床和研究使用中可以互换.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 生物统计学 生物统计学
背景情况:
- 头部和部状细胞癌 (HNSCC) 是癌症相关死亡的重要原因.
- 准确预测整体存活率对于患者管理和临床试验设计至关重要.
- 伴随性疾病指数越来越多地用于评估患者的预后.
研究的目的:
- 为了比较成人并发症评估-27 (ACE-27) 和查尔森并发症指数 (CCI) 对HNSCC患者整体存活的预测准确度.
- 为了确定一个并发症指数是否在这个特定的癌症群体中比另一个具有更高的预后价值.
主要方法:
- 在2010年至2013年期间接受治疗的1,193名HNSCC患者的回顾性分析.
- 卡普兰-梅尔分析确定了重要的预后共变量,包括年龄,HNSCC亚位,治疗,TNM阶段,烟草和酒精使用.
- 构建了两个Cox回归模型,一个包含ACE-27和另一个CCI,以使用c-统计学来评估它们对整体存活时间的影响.
主要成果:
- 在HNSCC患者中,ACE-27和CCI都与5年整体存活率有显著的相关性.
- 考克斯回归分析显示,CCI ≥5的危险比率 (HR) 为2.462,ACE-27得分为3.969的ACI ≥5和1.962.
- CCI模型的平均c-统计值为0.6783,而ACE-27模型的平均c-统计值为0.6790,表明可比的预测准确性.
结论:
- ACE-27和CCI都是HNSCC患者整体存活时间的独立预测指标.
- 在统计上,ACE-27和CCI的预测能力是相似的.
- 这些发现支持ACE-27和CCI在临床实践和HNSCC研究中的可互换使用.
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