饮食中的生物活性化合物和肠道微生物群之间的相互作用在调节与肥胖相关的炎症和代谢功能障碍方面
Maryam Seifishahpar1, Nishan Sudheera Kalupahana2, Jung Han Kim3
11Department of Nutritional Sciences, and Obesity Research Institute, Texas Tech University, Lubbock, Texas, USA.
Annual review of nutrition
|May 14, 2025
概括
饮食中的生物活性物质,如omega-3和植物化学物质,可以通过影响肠道微生物和线粒体来改善代谢健康. 这篇评论探讨了它们的复杂相互作用,以对抗与肥胖相关的炎症和功能障碍.
科学领域:
- 营养科学 营养科学
- 微生物学 微生物学
- 代谢健康 代谢健康
背景情况:
- 饮食中的生物活性化合物,包括omega-3多不和脂肪酸和植物化学品,通过减轻与肥胖相关的炎症和代谢功能障碍,为健康带来好处.
- 现有的研究往往忽视了这些生物活性物对肠道微生物群和线粒体功能的特定影响,这些是代谢疾病的关键因素.
- 肠道微生物群影响整体健康并调解饮食影响,而线粒体是能量代谢和与肥胖有关的功能障碍的核心.
研究的目的:
- 审查饮食中的生物活性物质,肠道微生物群和线粒体功能之间的相互作用.
- 阐明这些相互作用如何有助于缓解与肥胖相关的炎症和代谢功能障碍.
- 突出了解这些关系对于制定对代谢疾病的策略的重要性.
主要方法:
- 出版研究的文献综述.
- 对专注于饮食中的生物活性,肠道微生物群调节和线粒体功能研究的分析.
- 综合与肥胖,炎症和代谢功能障碍相关的发现.
主要成果:
- 饮食中的生物活性物调节肠道微生物群组成和代谢物,影响代谢健康.
- 肠道微生物群可以改变饮食中的生物活性物质,特别是植物化学物质的新陈代谢和生物可用性.
- 这些生物活性物质影响线粒体功能,特别是在脂肪组织中,影响能量代谢.
结论:
- 了解饮食中的生物活性,肠道微生物群和线粒体之间的复杂关系对于解决与肥胖有关的代谢功能障碍至关重要.
- 针对这些相互作用,有可能为针对代谢疾病的新疗法策略提供潜力.
- 需要进一步的研究来充分阐明这些机制并优化干预措施.
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