免疫性细胞死亡作为物理抗癌方式和免疫治疗之间的相互作用
Y Engelen1, R Demuynck2, J Ramon3
1Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, 9000 Ghent, Belgium; Cancer Research Institute Ghent (CRIG), 9000 Ghent, Belgium; Ghent Research Group on Nanomedicines, Faculty of Pharmaceutical Sciences, Ghent University, 9000 Ghent, Belgium.
概括
像聚焦超声波 (FUS) 这样的物理废弃疗法可以诱导免疫细胞死亡 (ICD),增强免疫系统.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 医学物理 医学物理
背景情况:
- 目前的癌症治疗面临的局限性包括耐药性,复发性和化学疗法等非特异性疗法的严重副作用.
- 物理除技术提供了有针对性的治疗,减少了患者的压力和更快的恢复.
- 放射疗法 (RT) 已经建立,但聚焦超声波 (FUS) 正在成为精确的物理剥离方法.
研究的目的:
- 审查物理废除疗法,特别是FUS如何利用免疫细胞死亡 (ICD) 来刺激抗癌免疫力.
- 探索这些疗法的潜力,以补充现有的免疫疗法,以改善癌症治疗结果.
- 要突出从彻底的瘤切除转向更温和的应用,诱导ICD没有显著的组织损伤的转变.
主要方法:
- 关于物理消去技术的当前文献的综述,重点是聚焦超声波 (FUS).
- 分析FUS诱导免疫细胞死亡 (ICD) 的机制.
- 探索ICD在刺激全身抗癌免疫反应和abscopal效应中的作用.
主要成果:
- 物理剥离疗法,特别是FUS,可以诱导免疫细胞死亡 (ICD),这是一个警告并激活免疫系统对抗癌症的过程.
- 由FUS触发的ICD可以导致全身免疫反应,可能提高其他癌症治疗的疗效.
- 通过控制FUS的应用,可以通过诱导ICD而实现治疗效益,同时最大限度地减少对周围健康组织的损害.
结论:
- 物理剥离疗法,特别是FUS,代表了利用免疫系统对抗癌症的有希望的策略.
- 通过FUS诱导ICD提供了一种新的方法来增强抗癌免疫力并改善患者的治疗结果.
- 将FUS诱导的ICD与免疫疗法结合起来,对于推进癌症治疗范式具有重大潜力.
相关概念视频
01:27Tumor Immunotherapy
411
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
411
01:27Cytotoxic T Cells-mediated Immune Response
740
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
740
01:30Cancer Vaccines
278
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
278
02:49Cancer Therapies
7.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.5K
02:50Combination Therapies and Personalized Medicine
4.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K
01:40Cell-mediated Immune Responses
66.3K
Overview
66.3K