对抗类风湿性关节炎的叶酸功能化核心外多元/奇托桑纳米颗粒的合成和表征
Afifa Shafiq1, Safiullah Khan2, Sadia Rahman1
1Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan.
International journal of biological macromolecules
|May 14, 2025
概括
含有甲状腺素的叶酸结合纳米颗粒显示为治疗类风湿性关节炎的前景. 这些新型纳米粒子提供持续的药物释放和增强的治疗效果,提高了安全性和生物相容性.
科学领域:
- 纳米技术 纳米技术
- 材料科学 材料科学 材料科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 有针对性的药物输送系统对于治疗诸如类风湿性关节炎等疾病至关重要.
- 叶酸受体在炎症组织中过度表达,使它们成为药物输送的理想目标.
研究的目的:
- 为了制定和描述含有甲状腺素的,与叶酸结合的核心外聚合物纳米粒子 (PF/CS).
- 评估这些针对性纳米颗粒的体外和体内疗效和安全性,用于类风湿性关节炎治疗.
主要方法:
- 使用自化和离子凝合成的纳米粒子.
- 描述包括尺寸,PDI,泽塔潜力,光谱学 (NMR,FTIR),热分析 (DSC,TGA) 和XRD.
- 在实验室中进行了药物释放,细胞毒性,血液相容性和急性毒性研究.
- 此外,还进行了体内疗效和模拟模型.
主要成果:
- PF/CS纳米颗粒表现出最佳尺寸 (<0.5 PDI),稳定性和已确认的叶酸结合.
- 观察到持续药物释放长达72小时,以及对巨细胞的增强细胞毒性.
- 活体和急性毒性研究证实了生物相容性和安全性.
- 在体内研究表明,增强治疗效果,在模型的支持下.
结论:
- 叶酸结合的PF/CS纳米颗粒代表了持续的甲状腺递送的可行平台.
- 这种方法显示出改善类风湿性关节炎治疗结果的巨大潜力.
- 该研究强调了针对炎症性疾病的基于纳米粒子的向药物输送的优势.
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