基于IgE的过敏测试在亚托匹性皮肤炎的演变:我们站在哪里?
Camille Braun1, François Graham2, David M Fleischer3
1Department of Pediatrics, Pneumology, Allergy, Cystic Fibrosis, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Bron, France; Centre International de Recherche en Infectiologie, INSERM U1111, CNRS UMR 5308, Université Lyon 1, ENS de Lyon, Lyon, France.
概括
亚托皮炎 (AD) 管理需要仔细考虑过敏症. 虽然食物过敏原可以触发AD,但IgE过敏测试通常不可靠;保持口服食物暴露是预防食物过敏的关键.
科学领域:
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
- 过敏 过敏是一种过敏.
背景情况:
- 亚托皮炎 (AD) 病理生理学涉及皮肤炎症,主要是由天生的免疫和T细胞驱动的,免疫球蛋白E (IgE) 在大多数情况下都起轻微的作用.
- 阿尔茨海默病患者的皮肤屏障缺陷增加了对环境抗原的敏感性,并增加了患食物过敏的风险.
- 由于病情的复杂性,艾滋病患者IgE介导过敏测试的作用仍然是争论的主题.
研究的目的:
- 为了澄清IgE介导过敏测试在阿托皮性皮肤炎 (AD) 患者中的相关性.
- 强调口服食物暴露对预防无形个体食物过敏的重要性.
- 为了指导临床实践,关于食品过敏原管理在AD.
主要方法:
- 对有关亚托邦性皮炎病理生理学和过敏测试的现有文献的综述.
- 对阿尔茨海默病患者皮肤刺伤测试和特定IgE测量的诊断价值的分析.
- 对食用抗原暴露对食物过敏发展的影响的评估.
主要成果:
- 在大多数AD病例中,IgE的作用有限,因此IgE介导过敏测试的预测能力较低.
- 艾滋病患者的高IgE水平可能导致皮肤刺痛测试和特定IgE测试的阳性预测值较低.
- 口服接触食物对于预防或延迟食物过敏的发作至关重要.
结论:
- 在AD中IgE过敏测试应保留在直接过敏反应 (如疹或血管) 的病例中,而不是湿疹.
- 保持饮食食品对于防止IgE介导的食物过敏的发展至关重要,尽管它们可能对AD有所贡献.
- 管理食物问题AD患者的主要目标应该是控制这种情况,同时确保持续通过饮食接触潜在的过敏原.
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