管理衰老的囊性纤维化患者群体:挑战和优先事项
Freddy J Frost1,2, Daniel G Peckham3, Imogen C Felton4
1Adult Cystic Fibrosis Centre Liverpool Heart and Chest Hospital NHS Foundation Trust, Liverpool, UK ffrost@liverpool.ac.uk.
概括
患有囊性纤维化 (pwCF) 的人因医学进步而活得更长. 未来的护理必须解决衰老带来的独特健康挑战,重点关注生活质量.
科学领域:
- 肺部病理学 肺部病理学
- 老年学是一门学科.
- 遗传学 遗传学 是一个
背景情况:
- 增加患有囊性纤维化 (pwCF) 的人的预期寿命需要将护理转向管理与年龄相关的复杂性.
- 早期诊断,多学科护理和CFTR调节器疗法的进展显著改善了pwCF的结果.
- 衰老的CF人口带来了独特的健康挑战,需要专注的研究和适应的临床战略.
研究的目的:
- 审查关键挑战和研究重点,以满足患有囊性纤维化症的老龄化人口的健康需求.
- 突出 pwCF 护理的不断变化的格局,考虑到寿命延长和治疗进步的影响.
- 确定新出现的问题,并提出多学科的研究方法,全面的健康在老龄化 pwCF.
主要方法:
- 文献综述综合了关于囊性纤维化衰老的当前证据.
- 分析pwCF的研究缺口和管理与年龄有关的疾病的未来优先事项.
- 整合临床,患者和社区的观点,以制定综合护理策略.
主要成果:
- 衰老的pwCF面临癌症,心血管疾病和改变代谢特征的风险增加.
- CFTR调节器显示出有希望的结果,但对炎症,免疫和疾病轨迹的长期影响需要进一步研究.
- 营养管理,肥胖,加速免疫/肺衰老,更年期,抗菌素耐药性和慢性炎症是关键考虑因素.
结论:
- 有效地管理衰老的pwCF需要多学科的研究,整合不同的观点.
- 利用CF注册,临床试验网络和衰老研究合作是至关重要的.
- 目标是确保老龄化的pwCF不仅活得更长,而且还可以改善生活质量和整体福祉.
相关概念视频
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Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
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Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed.
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Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed.
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Assessment
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