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暴露于挥发性有机化合物和女性不孕症之间的关联:NHANES分析

Liang-Sien Chen¹, Hung-Keng Wu², Wen-Hsin Chang²

¹School of Public Health, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 11031, R.O.C, Taiwan; Department of Family Medicine, Chang-Gung Memorial Hospital, Linkou Branch, 5 Fu-Xing Street, Taoyuan, 333423, R.O.C, Taiwan.

Taiwanese journal of obstetrics & gynecology

|May 14, 2025

概括

暴露于特定挥发性有机化合物 (VOC) 与女性不孕症风险增加有关. 这项研究确定了与女性生育能力下降相关的关键尿液VOC代谢物,突出了潜在的生殖健康问题.

科学领域:

环境健康环境健康
生殖毒理学生殖毒理学
流行病学流行病学

背景情况:

不孕症影响着全球大量人口,受各种因素的影响.
挥发性有机化合物 (VOC) 是常见的环境污染物,具有已知的不良健康影响.
挥发性有机化合物的对女性生育能力的具体影响在很大程度上仍未被描述.

研究的目的:

研究尿液中挥发性有机化合物 (VOC) 代谢物水平与女性不孕症之间的关联.
确定可能对女性生殖健康构成风险的特定VOC.

主要方法:

国家健康和营养检查调查 (NHANES) 数据 (2013-2018) 的横截面分析.
包括1097名年龄在18-45岁的女性,具有可用的生殖健康和尿液VOC代谢物数据.
单变量和多变量回归分析以评估VOC代谢物和不孕症之间的关联.

主要成果:

在12种尿液中特定的VOC代谢物和增加不孕症可能性之间发现了显著的关联.
N-Acetyl-S-3,4-dihydroxybutyl) -l-cysteine (DHBMA) 和N-Acetyl-S-2,2-hydroxypropyl) -l-cysteine (2HPMA) 显示了与不孕症的最强的联系.
调整后的几率比率表明,暴露于这些代谢物时,不孕症风险显著增加.

结论:

尿液中的特定VOC代谢物与女性不孕不育的可能性更高显著相关.
这些发现提供了与VOC暴露相关的生殖健康风险的初步证据.
需要进一步的研究来确定因果关系,并了解将VOC与女性不孕症联系在一起的机制.

关键词:

女性不孕症女性不孕症国家健康和营养检查调查 (NHANES)挥发性有机化合物 (VOC) 是一种挥发性有机化合物.

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