在全基血造干细胞移植后进行高剂量颗粒细胞输血的预防性治疗
Yannis Hadjiyannis1, Robert Bubar1, Darrell J Triulzi1,2
1Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Vox sanguinis
|May 14, 2025
概括
高剂量预防性粒细胞输血 (PGTxs) 在高风险干细胞移植患者中可行且耐受良好. 这种方法显示出在患有严重移植前感染的患者中预防感染的潜力.
科学领域:
- 血液学 血液学 血液学
- 输血医学 输血医学
- 在瘤学瘤学.
背景情况:
- 预防性颗粒细胞输血 (PGTxs) 由于混因素和缺乏预防性使用数据而引起争议.
- 很少有研究报告了继发性PGTx,用于血液造血干细胞移植 (HSCT) 中持续性,严重的移植前感染.
研究的目的:
- 审查高剂量PGTx的可行性,安全性和实施情况.
- 评估高风险HSCT患者的PGTx,这些患者有持久性,复发性感染的病史.
主要方法:
- 从2018年至2021年接受高剂量PGTx的HSCT患者的回顾性审查.
- 捐赠者用粒细胞殖民地刺激因子和甲进行刺激.
- PGTx是作为二次预防药物使用的.
主要成果:
- 七名患者接受了PGTx;95%的产品达到目标剂量 (≥0.6 × 10^9/kg).
- 输血后绝对中性粒细胞数 (ANC) 显著增加 (平均为5.5 × 10 ^ 9 / L).
- PGTxs耐受性良好,没有任何不良事件或与免疫接种;观察到高生存率 (100%在第30天) 和无发烧率 (85%).
结论:
- 优化的高剂量PGTx是可行的,耐受性很好,并且在高风险的HSCT患者中增加ANC.
- 虽然疗效和安全性需要进一步确定,但这项研究表明了优化高剂量PGTx对这一群体的潜力.
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