通过阿波利波蛋白L蛋白向共生体调节肠道免疫力
Tao Yang1, Xiaohu Hu1, Fei Cao2
1Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Nature
|May 14, 2025
概括
小鼠肠道细胞释放着通过胺-1-酸盐脂质覆盖细菌的阿波利波蛋白L9a/b (APOL9a/b). 这种相互作用增强了宿主免疫力,促进了肠道健康.
科学领域:
- 微生物组研究
- 免疫学
- 主体与微生物的相互作用
背景情况:
- 哺乳动物的肠道微生物通过生物活性分子与宿主相互作用.
- 主体从共生关系中获益的策略尚未得到充分探索.
研究的目的:
- 调查宿主分泌的因素, 以促进有益的肠道共生关系.
- 确定宿主从共生细菌中获益的机制.
主要方法:
- 流细胞计分类APOL9结合细菌.
- 16S核糖核酸基因测序 (APOL9-seq).
- 对细菌胺-1-酸盐合成的基因操纵.
主要成果:
- 小鼠肠细胞分泌APOL9a/b,这些细菌通过胺-1-酸盐 (Cer1P) 脂质特别覆盖细菌.
- APOL9a/b涂层诱导细菌产生外膜囊泡 (OMV).
- 细菌类衍生OMV增强宿主干扰素γ信号传递和主要组织相容性复合体II类表达.
结论:
- 由宿主分泌的APOL9a/b通过向细菌Cer1P来促进肠道免疫稳定.
- 通过APOL9a/b介导的OMV增强了宿主免疫屏障功能.
- 失去APOL9a/b会影响免疫功能,增加对病原体的敏感性.
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