使用废弃物衍生Citrus aurantifolia皮质质素作为聚合物来优化furosemide浮动生物粘合剂矩阵片的配方
Ebrahim Abdela Siraj1,2, Yohannes Mulualem1, Fantahun Molla1
1Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Scientific reports
|May 14, 2025
概括
果皮皮素被探索为天然聚合物用于胃药物输送. 优化的配方显示出有利的浮动性和粘粘性,这表明素是可行的制药辅助剂.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
背景情况:
- 自然聚合物越来越多地被研究为先进的药物输送系统.
- 胃阻塞药物输送旨在延长药物在胃中的停留时间.
- 素是一种天然的多糖,显示出作为功能辅助剂的潜力.
研究的目的:
- 为了评估果皮素作为浮动和粘粘性聚合物用于胃药物输送.
- 为了优化基于pectin的配方,使用furosemide作为模型药物.
- 评估提取的pectin的兼容性和性能.
主要方法:
- 通过热水提取,从 (Citrus aurantifolia) 皮中提取点.
- 福里埃变换红外光谱 (FTIR) 和差分扫描热量计 (DSC) 用于兼容性分析.
- 中央复合设计 (CCD) 优化配方变量 (pectin和泡剂度) 和响应变量 (浮动时间,生物粘合强度,胀指数,药物释放).
主要成果:
- 果皮产生的纯化pectin (34.4%),具有很高的化程度 (85.49%).
- FTIR和DSC证实了pectin与furosemide的兼容性.
- 优化的配方 (22.3%的pectin,5%的泡剂) 预测了有利的漂浮时间 (14.07秒),生物粘合强度 (28.57克),胀指数 (254.08%) 和药物释放 (1小时后27.86%).
- 实验验证证证实了优化药片配方的预测特征.
结论:
- 来自废弃物的果果果是一种合适且丰富的替代制药辅助剂.
- pectin有效地赋予浮动和粘粘性质的矩阵片.
- 开发的胃系统显示了改善药物输送的潜力.
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