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Updated: Aug 8, 2026

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
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对恶性外围神经膜瘤的基因组分析和病理评估

Qian Cui1, Fen Zhang1, Jian Liu1

  • 1Department of Pathology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Zhongshan 2nd Road, Guangzhou, 510080, China.

Journal of cancer research and clinical oncology
|May 14, 2025
PubMed
概括

基因组分析有助于恶性外围神经膜瘤 (MPNST) 的诊断和治疗. 识别特定的突变,如CDKN2A,影响无病生存,指导个性化的MPNST疗法.

关键词:
有作用的基因.差异诊断是一种差异诊断.MPNST MPNST 的意思是分子特征是分子特征.

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The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...