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儿童严重 pertussis 的危险因素和交换输血的应用
Qihong Chen1,2,3, Lihua Lin1,2,3, Shuping Xiong1,2,3
1Department of Pediatrics, the First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China.
儿童的严重 pertussis 预测年龄较小,缺乏 DTaP 疫苗接种,呼吸短促和高白细胞 (WBC) 计数. 交换输血有效治疗严重的肺高血压病例.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 百日咳或百日咳仍然是一个重要的公共卫生问题,特别是在婴儿和幼儿中.
- 接种疫苗,主要是通过DTaP (白喉,结节炎和非细胞性百日咳) 疫苗,是预防的基石.
- 识别严重疾病的风险因素对于及时干预和改善结果至关重要.
研究的目的:
- 确定与儿科患者严重百日咳相关的关键风险因素.
- 评估交换输血作为治疗性干预严重百日咳并发症的有效性.
主要方法:
- 儿童百日咳病例的回顾性分析,比较轻度和严重的表现.
- 使用的医院数据包括人口统计,临床症状,实验室发现,心声回声和并发症.
- 雇佣的接收器运行特征 (ROC) 分析,以确定严重咳的预测因素.
主要成果:
- 严重的 pertussis 病例呈现出早期发病,性咳,呼吸短促和rales.
- 确定的主要危险因素包括缺乏DTaP疫苗接种,年轻的年龄,呼吸困难和白细胞 (WBC) 计数升高 (WBC> 27.93 × 10^9/L).
- 交换输血有效地使肺高血压正常化,并改善了患有白细胞计数增加和呼吸困扰的患者的治疗结果.
结论:
- 年轻的年龄,未接种疫苗的状态 (没有DTaP),呼吸短促和高的白血球数量是严重百日咳的重要预测因素.
- 一个WBC数量大于27.93×10^9/L可以作为一个强大的生物标志物来预测疾病的严重程度.
- 交换输血是一种有益的干预措施,用于严重的 pertussis 病例复杂的肺高血压和显著增加的白细胞计数.
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