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皮南牛的CNV地图构造和ROH分析

Xingya Song¹, Zijing Zhang², Shengyan Xing¹

¹College of Animal Science and Technology, Northwest A&F University, No. 22 Xinong Road, Yangling, Shaanxi, 712100, People's Republic of China.

|May 14, 2025

概括

由于交叉繁殖,Pinan牛表现出了出色的生长特征. 全基因组再测序揭示了独特的遗传变异和较低的近亲繁殖风险,确定了肌肉和生殖发育的关键基因.

科学领域:

基因组学就是基因组学.
动物育种动物育种
人口遗传学人口遗传学

背景情况:

皮南牛是南阳和皮埃蒙特牛的杂交品种,表现出优越的生长性能.
了解它们的遗传构成对于进一步的品种改进至关重要.

研究的目的:

为了构建一个全面的副本数变化地图Pinan牛.
分析种群的遗传结构和近亲繁殖水平.
识别与理想特征相关的候选基因.

主要方法:

在132头平南牛的全基因组重新测序中.
复制数变化 (CNV) 和CNV区域 (CNVR) 分析.
使用CNVR进行种群遗传结构分析.
在同胞繁殖中运行同胞性 (ROH) 分析.
对候选基因进行选择分析 (VST,ROH岛屿,iHS).

主要成果:

删除类型的CNV普遍存在,很少有重叠的异构区域.
皮南牛在遗传上是不同的,更接近南阳牛.
皮南牛的内生繁殖水平低于欧洲肉牛.
确定了用于肌肉,生殖,胚胎发育和免疫力的候选基因.

结论:

通过CNV分析,可以明确区分Pinan牛的基因.
低亲生繁殖表明风险低,支持品种的可持续性.
鉴定出来的基因为了解和增强平南牛的优秀特征提供了基础.

关键词:

副本数量变化的变化遗传结构遗传结构杂交的程度是内在的皮南的牛群是什么意思运行 homozygosity 的运行.选择分析选择分析

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