发现与糖尿病并发症相关的微RNA:元分析和途径建模方法
Ruiyang Yin1, Yanjiao Zhang1, Xinyi Fang1,2
1Institute of Metabolic Diseases, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China.
BMC medical genomics
|May 14, 2025
概括
微RNAs (miRNAs) 与糖尿病并发症有关. 本综述确定了差异表达的miRNA及其标,突出了它们作为糖尿病脏病,视网膜病,神经病和心脏病等疾病的诊断和治疗生物标志物的潜力.
科学领域:
- 内分泌学和新陈代谢学
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 微RNAs (miRNAs) 调节基因表达,在糖尿病并发症的发病过程中至关重要.
- 糖尿病并发症包括糖尿病病 (DN),糖尿病视网膜病 (DR),糖尿病神经病 (DNP) 和糖尿病心脏病 (DC).
研究的目的:
- 研究糖尿病病,视网膜病,神经病和心脏病中的微RNA表达模式.
- 为了确定糖尿病并发症的潜在微RNA生物标志物.
主要方法:
- 在遵守PRISMA指南的基础上进行系统审查.
- 在PubMed,Embase和Web of Science数据库中进行文学搜索.
- 使用miRPath (DIANA) 的途径丰富分析和使用DIANA microT-CDS和TargetScan.can的目标基因预测.
主要成果:
- 选择了71项研究,揭示了79个在糖尿病并发症中差异表达的miRNA.
- miRNA126和miRNA192是经常报告的miRNAs之一.
- 确定了156个向基因和103个KEGG通路.
结论:
- 失调的miRNA显示出作为糖尿病并发症循环生物标志物的潜力.
- 需要进一步的研究和纵向研究来验证miRNA作为诊断和治疗点.
- 本综述提供了miRNAs在糖尿病并发症病理生理学中的作用的证据.
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