相关实验视频
与反复的自发早产相关的阴道微生物群的特征:一个前性队列研究
Xiang Jiang1, Yirong Bao1, Xiang Li1
1Shanghai Key Laboratory of Maternal-Foetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, No. 2699, Gaoke Road, Shanghai, 200092, China.
Journal of translational medicine
|May 14, 2025
概括
阴道乳杆菌在16周前占主导地位增加了复发的自发早产风险. 这表明,早期准阴道微生物群可以预防sPTB复发.
科学领域:
- 微生物学 微生物学
- 产科 产科 产科 产科 产科
- 遗传学 是一个遗传学.
背景情况:
- 由于原因不明,反复发生的自发早产 (sPTB) 缺乏有效的干预措施.
- 阴道微生物群在sPTB复发风险中的作用需要进一步调查.
研究的目的:
- 调查阴道微生物群组成与复发性sPTB的风险之间的关联.
- 确定与sPTB复发相关的特定微生物模式.
主要方法:
- 对152名高风险孕妇进行前性队列研究.
- 在怀孕早期和晚期进行顺序性阴道拭子采集和16S rRNA测序.
- 纵向分析比较复发性与非复发性sPTB组中的微生物群.
主要成果:
- 在34.9%的参与者中出现了复发性sPTB.
- 乳酸菌内体 (L. iners) 和乳酸菌 (L. crispatus) 是主要的区分因素.
- 复发的sPTB与L. iners主导 (CST III) 和非乳杆菌主导 (CST IVA,IVB) 状态有关,而非复发与L. crispatus主导 (CST IA) 状态有关.
结论:
- 怀孕早期L. iners的优势与增加sPTB复发风险有关.
- L. iners 的优势可能会导致不利的转向非 Lactobacillus 状态.
- 阴道微生物群调节是一个潜在的干预目标,用于预防复发的sPTB.
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