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Updated: May 17, 2025

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解读SHP2-E76突变的结构和动态影响:对瘤原性激活的机制性见解

Humaira Rafiq1, Lu Han2, Ashfaq Ur Rehman3

  • 1Department of Biochemistry, Abdul Wali Khan University Mardan, Mardan-23200, Pakistan.

BMC chemistry
|May 14, 2025
PubMed
概括

在SHP2蛋白中的功能获取突变破坏了其自身抑制,导致活性增强. 与癌症相关的突变会导致比与神经发育障碍相关的突变更严重的结构性破坏.

关键词:
癌症 癌症 癌症 癌症模拟MD的模拟方法突变突变是一种突变.在PTPN11中,在 SHP2 中, SHP2 是 SHP2.

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