在阻塞性睡眠呼吸暂停下综合征中先进的氧化蛋白产品-一个系统性审查和元分析
Shen-Sui Li1, Xu-Dong Tian1, Ju-Kun Song1
1Department of Oral and Maxillofacial Surgery, Stomatological Hospital of Guizhou Medical University, Guiyang, Guizhou, China.
Journal of oral rehabilitation
|May 15, 2025
概括
这项研究发现,在患有阻塞性睡眠呼吸暂停缺血综合征 (OSAHS) 的患者中,高级氧化蛋白产品 (AOPP) 的水平较高. 这些发现表明,AOPP可能有助于OSAHS发展.
科学领域:
- 生物化学 生物化学
- 睡眠医学 睡眠医学
- 氧化压力研究研究 氧化压力研究
背景情况:
- 阻塞性睡眠呼吸暂停症候群 (OSAHS) 是一种常见的睡眠障碍.
- 以前的研究表明,OSAHS和氧化应激生物标志物 (如高级氧化蛋白产品 (AOPP)) 之间存在联系.
- 需要进一步澄清AOPP水平和OSAHS之间的确切关系.
研究的目的:
- 系统地审查和定量合成关于AOPP水平与OSAHS之间的关联的证据.
- 评估AOPP作为OSAHS潜在生物标志物的作用.
主要方法:
- 在多个数据库中进行了全面的文献搜索,截至2023年10月.
- 在查后,包括了9项涉及608名OSAHS患者和770名对照者的研究.
- 统计分析,包括元分析和元回归,使用标准化平均差异 (SMD) 进行.
主要成果:
- 分析显示,与对照组相比,OSAHS患者的AOPP度显著增加 (SMD = 1.66).
- 超回归表明,出版年和BMI与效应大小有显著的关联.
- 在OSAHS患者中也观察到高水平的超氧化物脱酶 (SOD) 和甲 (MDA).
结论:
- 这一元分析证实,在OSAHS患者中,AOPP度显著更高.
- 这些发现表明,AOPP在OSAHS的发病过程中发挥了作用.
- 在OSAHS的未来临床研究中,AOPP可能会成为一个有价值的生物标志物.
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