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在MASLD-MASH-HCC的发展中的微环境和MASH-HCC中MASH-HCC的相关治疗作用

Qiulin Wu¹, Yan Yang¹, Shixun Lin¹

¹Department of General Surgery, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.

Frontiers in immunology

|May 15, 2025

概括

与代谢功能障碍相关的脂肪性肝病 (MASLD) 涉及肝脏变化并影响肝脏微环境. 本综述探讨了MASLD进展中的细胞和微生物变化以及代谢相关的脂肪肝炎和肝癌的治疗点.

科学领域:

肝病学肝病学是一种肝病学.
免疫学免疫学免疫学
微生物学微生物学

背景情况:

与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的全球健康问题,包括从肝脂肪症到代谢相关的脂肪性肝炎 (MASH) 的疾病.
肝脏的微环境在MASH,肝纤维化和肝细胞癌 (HCC) 的进展中发挥着关键作用.
生活方式的变化导致全球MASLD的发病率和流行率在流行级增加.

研究的目的:

审查MASLD进展期间肝脏微环境中的动态变化.
检查各种肝细胞和肠道微生物群在MASLD病变发生中的作用.
讨论针对MASLD-MASH-HCC微环境的潜在治疗策略.

主要方法:

综合性文献综述,重点关注细胞和分子机制.
对研究肝细胞组件的研究分析:肝细胞,胆细胞,LSEC,HSC,KC,DC,中性粒细胞,单细胞,T细胞,B细胞,NK细胞,NKT细胞和MAIT细胞.
包括对肠道微生物群对MASLD的影响的研究.

主要成果:

MASLD的进展涉及不同肝细胞群体和肠道微生物群的显著变化.
肝脏微环境中的细胞间通信对于MASH诱导的纤维化和HCC发展至关重要.
特定的细胞和微生物变化在MASLD到HCC的谱中被确定.

结论:

肝脏微环境是MASLD病变发生的关键因素,影响纤维化和HCC.
针对微环境的特定细胞和微生物组件提供了有前途的治疗途径.
对MASLD-MASH-HCC微环境相互作用的进一步研究对于开发有效的治疗方法至关重要.

关键词:

在HCC中,HCC是HCC.马什 (MASH) 是一个非常重要的产品.马斯尔德马斯尔德是什么意思微观环境是一个微观环境.治疗药物治疗药物

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