沙门氏菌LVR01触发了对抗性的双臂先天免疫记忆,这会影响抗瘤功效
Sofía Chilibroste1, Jéssica C Dos Santos2, Amy Mónaco1
1Departamento de Desarrollo Biotecnológico, Instituto de Higiene, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
Frontiers in immunology
|May 15, 2025
概括
沙门氏菌LVR01可能会诱导训练免疫力,增强抗瘤反应. 然而,它也会导致单细胞中的免疫,这可能解释了它在癌症治疗中的暂时效果.
科学领域:
- 免疫学 免疫学 免疫学
- 癌症研究 癌症研究
- 微生物学 微生物学
背景情况:
- 天生的免疫记忆涉及训练免疫和免疫耐受性,影响细胞对刺激的反应.
- 针对膀癌的Bacillus Calmette-Guérin (BCG) 免疫疗法利用训练有素的免疫力产生抗瘤作用.
- 沙门氏菌在癌症治疗中显示出潜力,但其作用是暂时的.
研究的目的:
- 调查沙门氏菌LVR01是否触发训练免疫力,类似于BCG.
- 评估沙门氏菌诱导的训练免疫对抗瘤反应的影响.
- 了解沙门氏菌对天生的免疫细胞的双重影响.
主要方法:
- 向小鼠注射沙门氏菌LVR01,并评估骨髓细胞的反应.
- 在沙门氏菌LVR01治疗和瘤植入后,评估了小鼠的抗瘤反应.
- 在实验室中用沙门氏菌LVR01.01刺激人类单细胞和小鼠髓状细胞.
主要成果:
- 沙门氏菌LVR01诱导了骨髓细胞中增强的细胞因子反应,表明受过训练的免疫力.
- 在老鼠中,沙门氏菌LVR01的使用导致瘤生长减缓和延长存活时间.
- 在体外,沙门氏菌LVR01导致人体单细胞和小鼠骨髓状细胞的细胞因子产量下降,类似于免疫.
结论:
- 沙门氏菌LVR01具有双重作用:诱导先天免疫记忆增强和单细胞.
- 这些相反的效应可能是沙门氏菌基癌症免疫疗法的短暂性质的基础.
- 对这些现象的进一步研究可以优化沙门氏菌免疫疗法治疗癌症.
相关概念视频
Cell-mediated Immune Responses
65.0K
Overview
65.0K
Special Features of Adaptive Immunity
3.7K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
3.7K
Cells of the Adaptive Immune Response
6.9K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
6.9K
Immunological Memory
12.3K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
12.3K
Defense Against Bacterial Pathogens
3.1K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
3.1K
Tumor Immunotherapy
2.6K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.6K


