在全身麻醉下的儿童中,LncRNA MALAT1 作为外科手术期间呼吸系统不良事件的危险因素
Yuan Gao1, Bo Wang2, Shuai Wang3
1Department of Anesthesiology, Jingzhou Hospital Affiliated to Yangtze University, No. 4, Renmin Road, Jingzhou District, Jingzhou 434020, Hubei Province, China.
Toxicology research
|May 15, 2025
概括
在接受全身麻醉的儿童中,长非编码RNAMALAT1水平升高可能预测外科手术期间呼吸系统不良事件 (PRAE). 这一发现有助于评估麻醉风险并改善患者的治疗结果.
科学领域:
- 麻醉学 麻醉学
- 分子生物学分子生物学
- 儿科医学 儿科医学
背景情况:
- 术后呼吸系统不良事件 (PRAE) 在儿科麻醉中很常见.
- 准确的手术前风险评估对于减轻手术风险至关重要.
研究的目的:
- 在患有PRAE的儿童中调查长非编码RNAMALAT1的表达水平.
- 评估MALAT1在儿科全身麻醉中对PRAE的预测性能.
主要方法:
- 对236名儿科病人的病历进行了回顾性分析,分为PRAE和非PRAE组.
- 使用qRT-PCR量化血清MALAT1水平.
- 多变量逻辑回归和ROC曲线分析,以评估风险因素和诊断性能.
主要成果:
- 与没有PRAE组相比,PRAE组的血清MALAT1水平显著更高.
- 较高的MALAT1水平,手术前的呼吸道疾病和更长的麻醉时间被确定为PRAE的危险因素.
- 在预测PRAE时,ROC分析显示曲线下的面积为0.885,对MALAT1具有79.44%的灵敏度和82.17%的特异性.
结论:
- 血清MALAT1的增加是预测在接受全身麻醉的儿童中PRAE的潜在指标.
- MALAT1作为PRAE预测的风险因素,具有可参考值.
- 这项研究有助于改善儿童麻醉的风险分层和管理.
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