在加州教师研究中,阿司匹林不会改变子宫内膜异位症中心血管事件的风险
Alison Seitz1, Cenai Zhang2, Leslie Bull3
1Department of Neurology, University of Washington, Harborview Medical Center, 325 9th Ave, Box #359775, Seattle, WA 98104, USA.
子宫内膜异位症增加了心血管疾病的风险,特别是在年轻女性. 阿司匹林不会改变这种关联,突出显示需要新的降低子宫内膜异位症患者风险的策略.
科学领域:
- 生殖健康 生殖健康
- 心血管医学 心血管医学
- 流行病学 流行病学
背景情况:
- 子宫内膜异位症是生育年龄妇女常见的疾病.
- 它与心血管疾病 (CVD) 的更高风险有关.
研究的目的:
- 确认子宫内膜异位症和心血管疾病风险之间的关联.
- 调查阿司匹林是否会改变患有子宫内膜异位症的女性心血管疾病风险.
主要方法:
- 一项纵向队列研究分析了加州教师研究 (1995-2020) 的数据.
- 主要不良心血管事件 (MACE) 使用验证的ICD代码进行识别.
- 使用逆概率 (IP) 权重来估计子宫内膜异位症对MACE的因果关系.
主要成果:
- 子宫内膜异位症与MACE的更高风险相关 (IP加权HR 1.10;95% CI 1.04-1.15).
- 这种风险增加在40岁以下的参与者中更为明显 (IP加权HR1.48;95%CI1.08-2.02).
- 服用阿司匹林并没有显著改变子宫内膜异位症和MACE之间的关联 (P相互作用=0.467).
结论:
- 子宫内膜异位症与心血管不良事件的风险增加有关,特别是在年轻女性中.
- 阿司匹林似乎没有减轻这种增加的心血管风险.
- 需要进一步的研究,以确定有效的策略,以减少患有子宫内膜异位症的个体心血管风险.
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