Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Depression: Overview01:18

Depression: Overview

201
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
201
Long-term Depression01:03

Long-term Depression

2.5K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.5K
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

23
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
23

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

PFN1 inhibits lytic replication of Kaposi sarcoma-associated herpesvirus through SQSTM1/p62-mediated selective autophagy targeting the KSHV helicase.

Autophagy·2026
Same author

Sex differences in resting-state hypothalamic connectivity and its relationship with negative emotion and behavior measures in young adults.

Brain structure & function·2026
Same author

Safety, tolerability, pharmacokinetics, pharmacodynamics and food effect of HRS-1893, a cardiac myosin inhibitor, in healthy subjects.

British journal of clinical pharmacology·2026
Same author

Transcriptional factor ATF3 impairs KSHV lytic replication by suppressing the expression of viral bZIP protein K8.

PLoS pathogens·2026
Same author

Multi-center-validated machine learning model for cervical cancer based on human papillomavirus genotyping results.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society·2026
Same author

Aggregate-mediated redistribution and bioavailability of cadmium in paddy soils under alternating redox conditions.

Journal of environmental sciences (China)·2026

相关实验视频

Updated: May 17, 2025

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

14.9K

白质功能连接体梯度功能障碍在严重抑郁症中

Baoxin Yu1,2,3, Xiaoyi Sun1,2,3,4, Mingrui Xia1,2,3

  • 1State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China.

Psychoradiology
|May 15, 2025
PubMed
概括

大型抑郁症 (MDD) 涉及到大脑白质 (WM) 功能组织的改变. 这项研究揭示了MDD患者合同的WM等级,与症状严重程度有关.

关键词:
大脑网络 大脑网络抑郁 抑郁症 抑郁症 抑郁症 是一种功能磁力共振成像 (fMRI) 是一种功能连接性的功能连接性层次结构的层次结构.白质功能网络是白质的功能网络.

更多相关视频

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
08:20

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

Published on: August 11, 2015

13.8K
Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
13:26

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

12.2K

相关实验视频

Last Updated: May 17, 2025

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

14.9K
MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
08:20

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

Published on: August 11, 2015

13.8K
Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
13:26

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

12.2K

科学领域:

  • 神经科学是一个神经科学.
  • 精神病学是一个精神病学.
  • 医疗成像医学成像

背景情况:

  • 重度抑郁症 (MDD) 是一种常见的精神疾病.
  • 在MDD中观察到大脑白质 (WM) 的干扰.
  • 在MDD中WM的精确组织尚不清楚.

研究的目的:

  • 为了研究白质 (WM) 功能连接体梯度在主要抑郁症 (MDD).
  • 在MDD患者中确定WM组织的全球和区域变化.
  • 探索WM梯度特性与抑郁症状严重程度之间的关系.

主要方法:

  • 使用了静止状态功能磁共振成像 (rs-fMRI) 数据.
  • 分析了48名MDD患者和68名健康对照组 (HC) 的数据.
  • 描述了WM功能连接体梯度,并进行了外部验证.

主要成果:

  • 与HC相比,MDD患者表现出合同的WM等级,降低了梯度范围和空间变化.
  • 特定的WM通道,包括未切割的囊 (UF) 和前面的胸膜辐射 (ATR),在MDD中显示了改变的梯度得分.
  • 在临床严重程度的差异中,WM通道梯度模式占37.2%.

结论:

  • 改变的WM功能连接体梯度是MDD的一个特征.
  • 这些变化与抑郁症状的严重程度有关.
  • 研究结果提供了对MDD神经生物学和潜在的生物标志物进行症状评估的见解.