动脉样硬化的进展和微血管功能障碍,心血管风险和癌症之间的关系的假设
Ansgar Adams1, Waldemar Bojara2, Michel Romanens3
1B·A·D Health Care and Safety Technology Centre GmbH, Koblenz, Germany.
Cardiology research
|May 15, 2025
概括
健康个体的动脉样硬化进展不能通过经典的风险因素来预测. 测量动脉斑块负担为心血管疾病和癌症提供了更好的风险分层.
科学领域:
- 心血管研究的心血管研究.
- 在瘤学瘤学.
- 医学成像医学成像
背景情况:
- 动脉样硬化程度测量在健康的男性和女性使用动脉超声波.
- 该研究调查了经典风险因素是否预测动脉样硬化进展.
- 一个假设探索了微血管功能障碍,动脉样硬化,心血管疾病和癌症之间的联系.
研究的目的:
- 为了评估动脉样硬化的程度和进展在健康的成年人.
- 确定动脉样硬化的经典风险因素的预测价值.
- 为了比较患有癌症和心血管事件的患者的风险概况和斑块负担.
主要方法:
- 动脉的超声波用于测量10597名受试者 (20-65岁) 的斑块面积和厚度.
- 对4520名受试者 (40-65岁) 进行了后续检查.
- 风险因素和斑块负担在患有固体瘤的男性和患有心血管事件的男性之间进行了比较.
主要成果:
- 晚期动脉样硬化 (III型和IVb型) 在12%的男性和4.2%的35-65岁女性中被发现.
- 40-65岁患者 (n=4,420) 的动脉样硬化进展无法通过经典风险因素预测.
- 与没有癌症或心血管事件的患者相比,患有癌症或心血管事件的患者表现出类似的高风险因素和斑块负担.
结论:
- 动脉斑块负担测量提供了跨年龄组有效的风险分层.
- 由于动脉样硬化进展不可预测,建议定期进行随访 (每3-5年).
- 晚期动脉样硬化的早期治疗可能会改善心血管疾病和潜在的某些癌症的结果.
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