VDR和VDBP基因多态的关系与败血症易感性和预后
Chan Lian1, Kangtai Ying1, Haiyan Shao1
1Department of Respiratory Medicine, The First People's Hospital of Wenling City, Wenling, Zhejiang, China.
Frontiers in genetics
|May 15, 2025
概括
维生素D受体 (VDR) 和维生素D结合蛋白 (VDBP) 基因的遗传变异与败血症风险有关. VDR Fok I f等位基和VDBP rs4588 A等位基增加了败血症的易感性.
科学领域:
- 遗传学 遗传学 是一个
- 分子生物学分子生物学
- 关键护理医学 关键护理医学
背景情况:
- 败血症是一种危及生命的器官功能障碍,是由宿主对感染反应失调引起的.
- 维生素D受体 (VDR) 和维生素D结合蛋白 (VDBP) 在免疫调节中起着至关重要的作用.
- 在VDR和VDBP中的遗传多态可能会影响败血症易感性和结果.
研究的目的:
- 调查VDR和VDBP基因多态和败血症易感性之间的关联.
- 评估这些多形态与败血症预后的相关性.
- 评估VDR和VDBP基因多态性在败血症的诊断价值.
主要方法:
- 病例控制研究比较了110名败血症患者和100名对照人群.
- 对VDR Fok I (rs2228570) 和VDBP rs4588多态的基因定型.
- 临床数据收集包括APACHE II,SOFA分数和血清生物标志物 (乳酸盐,CRP,PCT,维生素D).
- 接收器操作特征 (ROC) 曲线分析用于诊断评估.
主要成果:
- 与对照组相比,败血症患者的APACHE II,SOFA,乳酸,CRP,PCT水平较高,维生素D水平较低.
- 在败血症患者中观察到VDR Fok I f等位基因和VDBP rs4588 A等位基因的频率增加 (P <0.05).
- VDBP rs4588 AA 基因型显示了中度的败血症诊断值 (AUC = 0.579).
- 较高的APACHE II和SOFA评分,以及高的炎症标志物与败血症患者的死亡率增加有关.
结论:
- 在VDR Fok I (rs2228570) 位点的f等位基和在VDBP rs4588位点的A等位基与败血症的风险增加有关.
- 亚帕希II和SOFA分数是毒症预后的独立风险因素.
- VDR和VDBP基因多态可能作为毒症风险评估的潜在生物标志物.
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