脱脂症与维生素D缺乏症之间的关联:在中国健康人口中进行的横截面研究
Bin Li1, Jianhong Wang1, Jialie Xu1
1Department of orthopaedics, Yuhuan people's hospital, Taizhou, Zhejiang, China.
Frontiers in endocrinology
|May 15, 2025
概括
维生素D缺乏是常见的,并且与更高的脂质障碍症风险有关,特别是在女性中. 解决维生素D水平可能有助于管理脂质配置文件并降低健康风险.
科学领域:
- 内分泌学和新陈代谢学
- 临床生物化学 临床生物化学
- 公共卫生 公共卫生
背景情况:
- 维生素D缺乏的全球流行需要了解其对健康的影响.
- 维生素D在各种生理过程中发挥作用,包括脂质代谢.
- 血清25-氧维生素D (25(OH) D) 水平是维生素D状态的关键指标.
研究的目的:
- 为了研究血清25(OH) D水平和脂质配置文件之间的关联.
- 为了确定维生素D缺乏是否会增加脱脂症的风险.
- 探索这种关联中潜在的性别特异性差异.
主要方法:
- 对1535个无症状个体进行横截面分析.
- 通过化学发光免疫测试测量血清25(OH) D.
- 使用自动化酶方法评估脂质参数 (总胆固醇,LDL-C,HDL-C,TG).
主要成果:
- 54.7%的参与者有维生素D缺乏 (平均25~OH) D: 49.6±15.3nmol/L).
- 雌性比雄性有显著较低的25OH) D水平.
- 维生素D缺乏与1.71倍更高的脂质障碍症风险有关,在女性中更为明显 (OR=2.84).
- 维生素D缺乏与女性LDL-C升高有关 (OR=5.17).
结论:
- 维生素D缺乏与增加血脂不良的风险显著相关.
- 这种关联在女性中尤为明显.
- 在管理维生素D缺乏和脂质不良症时,应考虑性别特异性因素.
相关概念视频
Lipids: Dietary Sources and Requirements
598
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
598
Cholesterol: Significance and Regulation
462
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
462
Blood Studies for Cardiovascular System III: Serum Lipid Profile
111
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
111
Role of Skin in Vitamin D Synthesis
4.9K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
4.9K
Lipid-derived Compounds in the Human Body
4.3K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
4.3K
Overview of Lipid Metabolism
876
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
876


