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儿童肥胖的内分泌后果:一个叙事审查
Maroun Badr1, Ghazwa El-Rabaa1, Marianne Freiha1
1Department of Pediatric Diabetes, Clinical Auxology and Obesity, Poznan University of Medical Sciences, Poznan, Poland.
Frontiers in endocrinology
|May 15, 2025
概括
儿童肥胖严重扰乱了儿童的内分泌系统,影响了胰岛素和甲状腺等激素. 这篇评论详细介绍了这些荷尔蒙变化及其对健康的影响.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 公共卫生 公共卫生
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 儿童肥胖是一个主要的公共卫生问题,具有广泛的健康影响.
- 儿童的过度肥胖会破坏正常的荷尔蒙调节,影响生长和新陈代谢.
- 与肥胖相关的内分泌失调会导致严重的健康问题,包括糖尿病和心血管并发症.
研究的目的:
- 提供关于儿童肥胖的内分泌后果的全面概述.
- 为了突出过度脂肪对儿童激素通路的影响.
- 强调了解这些相互作用对公共卫生战略的重要性.
主要方法:
- 这项工作是对儿童肥胖及其内分泌影响现有研究的综述.
- 它综合了调查肥胖儿童荷尔蒙失调的研究结果.
- 该审查侧重于受过重影响的关键内分泌系统.
主要成果:
- 儿童肥胖与胰岛素抵抗,高胰岛素血症和2型糖尿病风险增加有关.
- 甲状腺功能障碍和甲状腺激素水平的改变在肥胖儿童中很常见.
- 肥胖会影响下丘脑-垂体-腺轴,导致早期青春期并影响生长模式.
- 升高的瘦素水平可能会导致瘦素抵抗,使食欲调节复杂化.
- 皮质醇分泌量增加会增加代谢综合征和心血管问题的风险.
结论:
- 儿童肥胖会引发显著的内分泌干扰,包括代谢,甲状腺和生殖荷尔蒙失衡.
- 这些内分泌的变化可能导致长期的健康问题,如糖尿病,生长异常和心血管并发症.
- 预防,早期干预和管理的综合战略对于解决儿童肥胖对内分泌的影响至关重要.
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