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酒精消费对动脉样硬化的影响:系统审查和元分析
Jiayuan Song1, Jiuhua She2, Jinzhu Yin3
1College of Integrative Medicine, Changchun University of Chinese Medicine, Changchun, China.
Frontiers in nutrition
|May 15, 2025
概括
总体而言,酒精消费不会显著促进动脉样硬化. 然而,它可能会增加女性和特定人群的风险,受饮酒模式和动脉部位等因素的影响.
科学领域:
- 心血管医学 心血管医学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 动脉样硬化是一种广泛的慢性血管疾病,影响主要动脉.
- 饮食因素,包括酒精消费,都与动脉样硬化的进展有关.
- 关于酒精对动脉样硬化的特定影响的系统评估有限.
研究的目的:
- 调查酒精消费对动脉样硬化发展的影响.
- 通过元分析评估饮酒频率,性别和其他因素的缓和效应.
主要方法:
- 在PubMed,Embase,Cochrane和Web of Science数据库中进行全面的文献搜索.
- 对26项研究 (326,513名患者) 的分析,并按国家,研究类型,动脉部位,诊断标准,酒精类型和性别进行分组分析.
- 使用STATA 18.0进行数据提取和统计分析;与INPLASY注册的协议.
主要成果:
- 总体的元分析显示,酒精对动脉样硬化没有显著的促进作用 (OR = 0.91,95% CI 0.79-1.05).
- 亚组分析表明,在特定的国家 (日本,韩国,巴西,丹麦),研究类型 (队列,病例控制),动脉部位 (冠状动脉) 和诊断标准 (临床,CT) 中风险增加.
- 饮酒可能会增加女性动脉样硬化风险,与饮酒水平相关的风险有所不同.
结论:
- 饮酒和动脉样硬化之间的关系是复杂的,多因素的.
- 环境因素,病变位置和个体特征显著调节这种关系.
- 需要进一步的研究来阐明具体的机制和个性化风险评估.
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