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通过非编码RNA调节不同类型的细胞死亡:分子见解和治疗影响
Reshmi Kumari1, Satarupa Banerjee1
1Department of Biotechnology, School of Biosciences and Technology, VIT University, Vellore 632014, Tamil Nadu, India.
ACS pharmacology & translational science
|May 15, 2025
概括
非编码RNAs (ncRNAs),包括长非编码RNAs (lncRNAs),microRNAs (miRNAs) 和圆形RNAs (circRNAs),调节不同的细胞死亡类型. 这些ncRNAs具有治疗潜力,特别是在癌症治疗中.
科学领域:
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
- 遗传学 是一个遗传学.
背景情况:
- 非编码RNAs (ncRNAs) 是生物过程中的重要调节者,尽管它们不编码蛋白质.
- ncRNAs包括长非编码RNAs (lncRNAs),microRNAs (miRNAs) 和圆形RNAs (circRNAs),在核酸大小上有所不同.
- 这些分子是转录,后转录和表观遗传调节的关键.
研究的目的:
- 研究ncRNAs在各种细胞死亡模式中的调控作用.
- 要突出 lncRNAs,miRNAs 和 circRNAs 在亡,ferroptosis,cuproptosis,pyroptosis,disulfidptosis 和 necroptosis 的参与.
- 强调ncRNAs作为点的治疗潜力,特别是在瘤学中.
主要方法:
- 文献综述和对ncRNAs和细胞死亡现有研究的综合.
- 对ncRNA参与不同细胞死亡途径的分子机制的分析.
- 在癌症治疗中检查针对ncRNAs的治疗策略.
主要成果:
- ncRNAs在多种细胞死亡类型中关键调节基因表达和蛋白质功能.
- 特定的ncRNAs影响着亡基因转录,铁恒常,铜离子积累,炎症途径和体形成.
- 由于二硫化键过多而引起的脱硫脱症,涉及ncRNAs在细胞骨完整性和氧化应激反应中.
结论:
- 非编码RNA是各种细胞死亡机制的整体协调者.
- 向ncRNAs是一个有前途的治疗途径,特别是在癌症治疗中.
- 对细胞死亡途径中ncRNA功能的进一步研究可以解锁新的临床应用.
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