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Updated: May 17, 2025

Isolated Pancreatic Islet Treatment and Apoptosis Measurement
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甲基普雷尼索隆保护人类胰腺β细胞免受炎症引起的损伤

Miriam Paz-Barba1, Iris J A Peters1, Natascha de Graaf1

  • 1Department of Internal Medicine, Leiden University Medical Centre, Leiden, the Netherlands.

Transplantation direct
|May 15, 2025
PubMed
概括

短期甲基普雷迪尼索隆保护人类β细胞免受炎症. 这一发现对于胰腺和小岛移植至关重要,改善了移植的生存和功能.

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The endoplasmic reticulum (ER) of pancreatic β-cells synthesizes preproinsulin, which consists of a signal peptide, A and B chains, and a C-peptide. Preproinsulin is then cleaved and folded into proinsulin, which translocates to the Golgi apparatus for sorting and packaging into secretory granules. In these granules, enzymatic clipping generates insulin and C-peptide.
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Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
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