循环生长分化因子-15度和高血压风险:一个剂量-反应元分析
Zhengqing Yu1, Jianshu Gao2, Zhongwei Zhou3
1Department of Clinical Laboratory, Binhai County People's Hospital, Binhai, Jiangsu, China.
Frontiers in cardiovascular medicine
|May 15, 2025
概括
较高水平的生长分化因子-15 (GDF-15) 与高血压患病率的增加有关. 这种关联是非线性的,在更高的GDF-15度下,效应会平稳.
科学领域:
- 心血管医学 心血管医学
- 内分泌学 在内分泌学.
- 生物标志物 生物标志物
背景情况:
- 增长差异化因子-15 (GDF-15) 与不良的临床结果有关.
- 关于GDF-15与高血压之间的关系的数据有限.
- 这项研究量化评估了GDF-15与高血压患病率的关联.
研究的目的:
- 评估循环GDF-15水平与高血压患病率之间的定量关系.
- 探索GDF-15和高血压之间的剂量反应关联.
- 确定导致观察到关系异质性的因素.
主要方法:
- 来自PubMed,Web of Science和Embase的研究系统的元分析,截至2024年8月.
- 纳入标准:报告至少三个GDF-15类别中高血压患病率的研究.
- 分析包括了24项研究,共有35,904名参与者.
主要成果:
- 具有高GDF-15水平的个体表现出明显更高的高血压患病率 (OR 1.60,95% CI 1.37-1.88).
- 高血压的患病率每增加1ng/ml的GDF-15 (OR 1.24,95% CI 1.16-1.33) 增加了24%,高血压的患病率增加了24%.
- 观察到一种非线性剂量反应关系,在大约5.5 ng/ml GDF-15.5后,患病率出现平原或略有下降.
结论:
- 循环GDF-15与高血压患病率有积极且非线性联系.
- 在较高的GDF-15度下,这种关联平原化或略有下降.
- 参与者的年龄和糖尿病患病率是异质性的重要来源.
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