在冠状动脉再血管化后患有胸痛的患者中,Qu-shi-hua-tan的疗效和安全性:一项随机,双盲,安慰剂对照试验研究研究协议
Wenjing Xu1, Jingwei Wen1, Xijiu Li1
1The Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
Frontiers in cardiovascular medicine
|May 15, 2025
概括
这项研究评估了对冠心病 (CHD) 患者的Qu-shi-hua-tan (QSHTD),这些患者在冠心再血管化 (AACR) 后经历了心痛. 随机对照试验评估了QSHTD.
科学领域:
- 心脏病学 心脏病学
- 传统中国医学 (TCM) 是一种
- 临床试验 临床试验
背景情况:
- 冠心病 (CHD) 管理仍然是一个重大的临床挑战.
- 冠状动脉再血管化 (AACR) 后的胸痛需要有效的治疗策略.
- 昆石华丹 (QSHTD) 是一种用于治疗心脏病的经验性TCM配方.
研究的目的:
- 评估QSHTD在AACR患者中的有效性和安全性.
- 为QSHTD在CHD内部管理AACR中的作用提供强有力的证据.
- 坚持临床研究中的高方法和报告标准.
主要方法:
- 一个双盲,随机对照试验,涉及98名参与者.
- 参与者接受了标准护理加上QSHTD或安慰剂12周.
- 通过腺应激实时心肌输液回声心电图 (RTMPE) 评估的心肌动脉血流 (MBF) 是主要结局.
主要成果:
- 该研究旨在测量心肌动脉血流 (MBF) 的变化,作为主要终点.
- 二次结局包括加拿大心血管协会分类,西雅图心痛问卷得分,TCM症状评估和主要不良心脏事件 (MACE).
- 该试验旨在证明QSHTD对AACR的更高的疗效和安全性,与安慰剂相比.
结论:
- 这项试验将提供关于QSHTD对CHD患者AACR的疗效和安全性的证据.
- 这些发现有望支持将QSHTD整合到这些患者的标准护理中.
- 该研究强调严格的方法和结果的透明报告.
更多相关视频
相关概念视频
Antianginal Drugs: Calcium Channel Blockers and Ranolazine
413
Angina pectoris, a primary symptom of ischemic heart disease, requires careful pharmacological interventions. In this context, calcium channel blockers (CCBs) and ranolazine have emerged as crucial pharmacotherapeutic agents, providing deep insights into the complexities of angina management.
CCBs, a diverse class that includes dihydropyridines (nifedipine) and diphenylalkylamines (verapamil and diltiazem), exert their effect by blocking calcium channels in cardiac and smooth muscle cells. This...
CCBs, a diverse class that includes dihydropyridines (nifedipine) and diphenylalkylamines (verapamil and diltiazem), exert their effect by blocking calcium channels in cardiac and smooth muscle cells. This...
413
Antianginal Drugs: Nitrates and β-Blockers
459
In cardiovascular health, antianginal drugs combat angina pectoris — a condition marked by chest pain owing to diminished blood flow to the heart.
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
459
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
334
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
334
Imaging Studies for Cardiovascular System I:Echocardiography
274
Cardiac imaging studies encompass a wide range of noninvasive and minimally invasive techniques designed to visualize the heart's structure and function in detail. One such technique is echocardiography, which uses high-frequency ultrasound waves to produce detailed images of the heart, known as echocardiograms.
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...
274


