黄冈囊调节托芬代谢,通过Keap1/Nrf2/HO-1通路改善糖尿病病
Jiayu Su1, Ying Zhang1, Xuan Wang1
1The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, China.
Frontiers in pharmacology
|May 15, 2025
概括
黄冈囊 (HKC) 通过减少氧化应激和损伤,有效治疗糖尿病病 (DN). 它调节了托芬代谢和Keap1/Nrf2/HO-1通路,提供了新的治疗见解.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学是指药理学的学科.
- 传统中国医药 传统中国医药
背景情况:
- 糖尿病病 (DN) 是末期病的主要原因之一.
- 黄冈囊 (HKC) 是一种传统的中医药,用于慢性淋巴结膜炎.
- 在处理DN过程中HKC的机制尚不清楚.
研究的目的:
- 研究HKC对糖尿病病的治疗作用.
- 阐明HKC在DN处理中的潜在机制.
- 探索托代谢和Nrf2通路在HKC作用中的作用.
主要方法:
- 在db/db小鼠中诱导了DN;治疗组包括HKC (低剂量和高剂量) 和对照组.
- 通过生物化学指数,组织学 (HE,Masson,PAS染色) 评估损伤.
- 分析了氧化应激标记物 (ROS) 和Nrf2通路蛋白/mRNA;使用了代谢学和体外细胞模型.
主要成果:
- 在小鼠中,HKC显著降低了血糖和尿蛋白/肌素比率 (UACR).
- HKC治疗改善了损伤,减少了ROS,并通过Keap1/Nrf2/HO-1通路缓解了氧化应激.
- 代谢学分析表明,HKC调节托代谢和5-HT途径以改善损伤.
结论:
- 在糖尿病病中,HKC显示出治疗潜力.
- 通过调节托代谢和Keap1/Nrf2/HO-1通路,HKC具有保护作用.
- 这项研究为HKC治疗DN的机制提供了新的见解,支持其临床应用.
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