血MBL水平升高与未来静脉血栓栓塞的风险有关:亨特
Christabel Esi Damoah1, Solveig M Valderhaug1, Omri Snir1,2
1Thrombosis Research Group, Thrombosis Research Center, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø. (C.E.D., S.M.V., O.S., S.K.B., T.E.M., J.-B.H.).
Arteriosclerosis, thrombosis, and vascular biology
|May 15, 2025
概括
高水平的曼诺结合性莱克 (MBL) 与静脉血栓塞栓症 (VTE) 的风险显著增加有关. 这种高风险似乎部分是由于MBL相关的血清蛋白酶启动血栓生成.
科学领域:
- 免疫学 免疫学 免疫学
- 补充系统 补充系统
- 血栓形成的原因之一是血栓形成.
背景情况:
- 曼诺结合性莱克 (MBL) 是一种模式识别分子,激活了莱克补充通路.
- MBL与MBL相关的血清蛋白酶 (MASP) 循环,可以促进血栓生成.
- 结合MBL与病原体或改变宿主细胞启动了这些过程.
研究的目的:
- 调查血MBL水平与静脉血栓塞栓症 (VTE) 未来风险之间的关联.
- 探索MBL-MASP-1/2复合体在促进血栓生成中的作用.
主要方法:
- 一项以人口为基础的病例队列研究 (HUNT研究) 涉及294名VTE患者和1066个子队列.
- 血MBL水平使用基于SomaScan 7k的aptamer平台进行了量化.
- 使用Cox比例危险回归模型来评估VTE风险,并在体外测试中检查了MBL-MASP复合体的血栓生成.
主要成果:
- 在MBL水平的最高四分位数中的个人与最低四分位数相比,整体VTE风险增加了79%.
- 高的MBL水平与深静脉血栓形成的风险增加密切相关 (HR 2.50) 和未引起的静脉血栓形成 (HR 2.81).
- 已经证明,MBL-MASP-1/2复合物在体外促进了补充激活和血栓生成.
结论:
- 血MBL水平升高与未来VTE的风险更高有关.
- 增加的VTE风险可能部分由MBL-MASP-1/2复合体介导,在凝块形成地点启动血栓生成.
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