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斯诺RNAs U34 和 U35a:状细胞疾病并发症的新目标

Waseem Chauhan1, Sudharshan Setra Janardhana Shetty1, Shirin Ferdowsi1

  • 1Department of Physiology, University of Tennessee Health Science Center, Memphis.

Circulation research
|May 15, 2025
PubMed
概括

研究人员发现,Rpl13a小核子RNAs (snoRNAs) U34和U35a在状细胞疾病 (SCD) 红细胞中增加反应性氧物种 (ROS). 将这些snoRNA与反感性寡核酸向改善了小鼠中与SCD相关的条件.

关键词:
RNA,小核细胞的RNA.贫血,状细胞贫血,状细胞贫血抗氧化剂 抗氧化剂是一种抗氧化剂.内皮,血管内皮,血管内皮.有活性氧物种的反应性氧物种.

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