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最近在个人化管理前列腺癌的进步急性前列腺切除术后的生化复发后前列腺癌的个人化管理

Fabian Falkenbach^1,2, Jonas Ekrutt¹, Tobias Maurer^1,3

¹Martini-Klinik Prostate Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Current opinion in urology

|May 15, 2025

概括

前列腺切除术后的生化复发 (BCR) 可以通过先进的工具更好地管理. 前列腺特异性膜抗原PET/CT成像和新型生物标志物改善风险分层和个性化治疗,以更好地控制癌症.

科学领域:

在瘤学瘤学.
放射学放射学是一门学科.
基因组学就是基因组学.

背景情况:

根源性前列腺切除术后的生化复发 (BCR) 呈现出不同的预后结果.
个性化管理策略对于优化患者护理至关重要.

研究的目的:

审查最近成像和生物标志物的进展,以管理前列腺切除术后的BCR.
突出这些技术在个性化治疗决策中的作用.

主要方法:

关于前列腺特异性膜抗原 (PSMA) -PET/CT成像的当前文献的综述.
对新型生物标志物,基因组分类器和人工智能 (AI) 模型的分析.
评估它们对BCR风险分层和治疗计划的影响.

主要成果:

在BCR中,PSMA-PET/CT显著提高了微观病变的早期检测,超过了传统的分期.
在大约三分之二的病例中,根据PSMA-PET/CT发现,治疗计划会被修改.
以PSMA-PET/CT为指导的救生放射治疗改善了高风险BCR患者的无进展生存率.
生物标志物,基因组分类器和人工智能模型促进了个性化的治疗强化或缓解.

结论:

传统的风险因素 (格莱森评分,PSA) 仍然是BCR管理的基础.
除了新型生物标志物和人工智能之外,PSMA-PET/CT为个性化治疗策略提供了增强的能力.
这些进展有望改善治疗结果,并为生物化学复发患者提供量身定制的护理.

关键词:

生物化学复发的发生.前列腺癌是前列腺癌.前列腺特异性膜抗原成像成像复发性前列腺癌复发性前列腺癌

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