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Updated: May 16, 2025

Visualization of DNA Repair Proteins Interaction by Immunofluorescence
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Visualization of DNA Repair Proteins Interaction by Immunofluorescence

Published on: June 26, 2020

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蛋白质二硫化物异构酶的氧化还原活性在非同类末端连接修复中起作用,以防止DNA损伤

Sina Shadfar1, Fabiha Farzana1, Sayanthooran Saravanabavan1

  • 1Motor Neuron Disease Research Centre, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia.

Aging cell
|May 15, 2025
PubMed
概括

蛋白二硫化异构酶 (PDI) 是一种用于修复DNA损伤的新型治疗点. 它的氧化还原活性对于通过非同质末端结合 (NHEJ) 修复双链DNA断裂 (DSB) 至关重要,为治疗与年龄相关的疾病和癌症提供了潜力.

关键词:
造成的DNA损伤是DNA损伤.修复DNA的修复DNA的修复年龄化的衰老.癌症 癌症 癌症 癌症 癌症双链 DNA 断裂,导致双链 DNA 断裂.神经退行性疾病的情况.斑马鱼是一种斑马鱼.

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