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Updated: May 10, 2026

Expression of Recombinant Proteins in the Methylotrophic Yeast Pichia pastoris
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Published on: February 25, 2010

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从Pichia pastoris使用响应表面方法和人工神经网络来建模和优化复合托西利祖马布生产

Prabir Kumar Das1, Ansuman Sahoo1, Venkata Dasu Veeranki1

  • 1Biochemical Engineering Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, India.

Biotechnology and bioengineering
|May 15, 2025
PubMed
概括

在Pichia pastoris中优化定义介质显著提高了重组单克隆抗体 (mAb) 生产. 曼尼托和甘氨酸增强了全长的托西利祖马布 (TCZ),而和硫酸盐提高了Fab碎片的产量.

关键词:
这就是Pichia pastoris.托西利兹马布的使用方法人工神经网络的人工神经网络工事设计的设计.遗传算法是一种遗传算法.响应表面方法的方法.

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