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Updated: May 16, 2025

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
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TMEM219信号促进肠道干细胞死亡,并加剧结肠炎

Francesca D'Addio1,2, Giovanni Amabile3, Emma Assi1

  • 1International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, Department of Biomedical and Clinical Sciences, Università degli Studi di Milano, Milan, Italy.

The Journal of clinical investigation
|May 15, 2025
PubMed
概括

异常的肠干细胞 (ISC) 死亡,由跨膜蛋白219 (TMEM219) 驱动,加剧克罗恩病. 在炎症性肠病模型中,阻止TMEM219可以恢复粘膜的修复和愈合.

关键词:
细胞灭亡 (apoptosis) 是一种死亡的过程.胃肠病学 胃肠病学炎症性肠病是一种炎症性肠病.鼠标模型 鼠标模型干细胞是一种干细胞.

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