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Updated: May 16, 2025

Author Spotlight: Advanced Single-Molecule Techniques for Investigating Telomeric Protein-DNA Interactions
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Published on: August 30, 2024

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hTERT增加TRF2以诱导端粒紧缩并延长细胞复制寿命

Nancy Adam1, Yang Yang1, Mahbod Djamshidi1

  • 1Robson DNA Science Centre, Arnie Charbonneau Cancer Institute, Departments of Biochemistry & Molecular Biology and/or Oncology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Aging cell
|May 15, 2025
PubMed
概括

表达突变hTERT的人类细胞通过压缩端粒来避免衰老,而不是通过延长它们. 这种端粒紧缩,独立于长度,阻止DNA损伤信号和复制停止,提供了对癌细胞行为的见解.

关键词:
在TRF2稳定过程中,TRF2稳定hTERT 非正典活动衰老是一种老化.端粒聚类的结合.端粒紧缩的结合

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