与瘤相关的巨细胞促进瘤免疫逃脱的机制
Shengfen Li1,2, Mengxia Zhang2,3, Yuan Gao2,4
1Institute of Pharmacy & Pharmacology, University of South China, Hengyang 421001, China.
Carcinogenesis
|May 15, 2025
概括
与瘤相关的巨细胞 (TAMs) 促进瘤免疫逃生,阻碍免疫治疗. 用新疗法 (如CSF-1R抑制剂) 针对TAM提供了一个有希望的策略,以克服癌症抗药性并改善治疗结果.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 癌症研究 癌症研究
背景情况:
- 瘤免疫逃生是促进癌症进展和免疫治疗失败的关键机制.
- 瘤相关巨细胞 (TAMs) 是瘤微环境 (TME) 中的关键调节者.
- 人们越来越认识到TAMs在促进免疫逃避和对癌症疗法的耐药性方面的作用.
研究的目的:
- 阐明TAMs对瘤免疫逃生有助的机制.
- 突出TAM在各种癌症类型中的临床相关性.
- 确定针对TAM的新型治疗策略,以改善癌症免疫疗法.
主要方法:
- 对TAMs和瘤免疫逃生现有文献的审查.
- 对研究TAMs在抑制免疫细胞活性,抗原呈现和T细胞激活中的作用的分析.
- 检查针对TAM向治疗的临床试验数据.
主要成果:
- TAMs通过抑制免疫细胞和T细胞激活来抑制抗瘤免疫力.
- TAMs与癌症预后不佳和对治疗的耐药性有关.
- 例如,通过CSF-1R抑制剂和CD40激动剂向TAM,在临床试验中显示出潜在的潜力.
结论:
- 了解TAM介导的免疫逃脱对于推进癌症免疫治疗至关重要.
- 向TAM是一种有前途的方法,可以逆转免疫抑制并提高治疗效率.
- 新的治疗途径正在出现,以克服耐药性并改善癌症患者的治疗结果.
相关概念视频
The Tumor Microenvironment
6.5K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.5K
Metastasis
5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K
Adaptive Mechanisms in Cancer Cells
5.6K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.6K
Tumor Immunotherapy
411
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
411
Cell-mediated Immune Responses
66.3K
Overview
66.3K
Immune Surveillance by NK Cells and Phagocytes
954
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
954


